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- DOI 10.18231/j.ijpns.2025.010
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CrossMark
Surgical outcome of adolescent idiopathic scoliosis who are Vitamin D deficient
- Author Details:
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Ujjwal Kanti Debnath *
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Shweta Bhyri
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Biplab Maji
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Alaaeldin Ahmad
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Shubhadip Chakraborty
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Joydeep Das
Ujjwal Kanti Debnath *
Shweta Bhyri
Biplab Maji
Joydeep Das
Introduction: Patients with adolescent idiopathic scoliosis (AIS) have a higher prevalence of Vitamin D deficiency compared with healthy peers.
Hypothesis: Vitamin D deficiency in AIS patients do not have good functional outcome after posterior instrumented corrective spinal fusion.
Materials and Methods: A prospective consecutive study of sixty-two (62) children who underwent surgery for AIS had preoperative measurement of Vitamin D levels (ng/mL). All were followed-up for a mean duration of 2 years after surgery. Data was collected for back pain, socioeconomic status, curve magnitude, age and gender. Patients were categorized based on vitamin D level: deficient (<20>
Results: Sixty-two (62) AIS patients (47F: 15M) were studied who underwent posterior instrumented spine fusion. Mean age at time of surgery was 15.24 ± 4.5 years. Major coronal curves had a mean of 68.08 ±12 degrees preoperatively and 12.19 ± 4.2 degrees postoperatively. In this study, 35 (56.45 %) of patients were vitamin D deficient, 23 (37.09 %) were insufficient, and 4 (6.45 %) were sufficient. Although there was no correlation between Vitamin D level and Pain, Mental Health, or Satisfaction domains (p >0.05), Vitamin D-deficient patients were found to be younger than 18 years of age (p <0 p =0.010), p =0.049), p =0.007).>
Conclusion: AIS patients with Vitamin D deficiency (<20>
Keywords: Adolescent Idiopathic Scoliosis, Posterior lumbar fusion, Vitamin D Deficiency
References
- Holick MF. Vitamin D and bone health. J Nutr. 1996;126(4):1159S– 64S.
- Balioglu MB, Aydin C, Kargin D, Albayrak A, Atici Y, Tas SK, et al. Vitamin-D measurement in patients with adolescent idiopathic scoliosis. J Pediatr Orthop B. 2017;26(1):48–52.
- Lam TP, Yip BHK, Man GCW, Lee WYW, Tam EMS, Lee KM, et al. Effective therapeutic control of curve progression using calcium and vitamin D supplementation for adolescent idiopathic scoliosis – a randomized double-blinded placebo-controlled trial. Bone Abstracts. 2017:6:OCB
- Radhakrishnan M, Nagaraja S. Modified Kuppuswamy socioeconomic scale 2023: stratification and updates. Int J Community Med Public Health. 2023;10(11):4415–18.
- Slattery C, Verma K. Classifications in Brief: The Lenke Classification for Adolescent Idiopathic Scoliosis. Clin Orthop Relat Res. 2018;476(11):2271–6.
- Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96(7):1911–30.
- Bagó J, Pérez-Grueso FJ, Les E, Hernández P, Pellisé F. Minimal important differences of the SRS-22 Patient Questionnaire following surgical treatment of idiopathic scoliosis. Eur Spine J. 2009;18(12):1898–904.
- Wang WJ, Yeung HY, Chu WC, Tang NL, Lee KM, Qiu Y, et al. Top theories for the etiopathogenesis of adolescent idiopathic scoliosis. J Pediatr Orthop. 2011;31(1 Suppl):S14–27.
- Konieczny MR, Senyurt H, Krauspe R. Epidemiology of adolescent idiopathic scoliosis. J Child Orthop. 2013;7(1):3–9.
- Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet. 2012;44(5):491–501.
- Medina-Gomez C, Kemp JP, Estrada K, Eriksson J, Liu J, Reppe S, et al. Meta-Analysis of Genome-Wide Scans for Total Body BMD in Children and Adults Reveals Allelic Heterogeneity and Age- Specific Effects at the WNT16 Locus. PLoS Genet. 2012;8:e1002718.
- Ng SY, Bettany-Saltikov J, Cheung IYK, Chan KKY. The Role of Vitamin D in the Pathogenesis of Adolescent Idiopathic Scoliosis. Asian Spine J. 2018;12(6):1127–45.
- Lee WT, Cheung CS, Tse YK, Guo X, Qin L, Lam TP, et al. Association of osteopenia with curve severity in adolescent idiopathic scoliosis: a study of 919 girls. Osteoporos Int. 2005;16(12):1924–32.
- Hung VW, Qin L, Cheung CS, Guo X, Qin L, Lam TP, et al. Osteopenia: a new prognostic factor of curve progression in adolescent idiopathic scoliosis. J Bone Joint Surg Am. 2005;87:2709-16.
- Luo J, Pollintine P, Gomm E, Dolan P, Adams MA. Vertebral deformity arising from an accelerated“creep” mechanism. Eur Spine J. 2012;21(9):1684–91.
- Dickson RA, Stamper P, Sharp AM, Harker P. School screening for scoliosis: cohort study of clinical course. Br Med J. 1980(6235);281;265–7.
- Yawn BP, Yawn RA, Hodge D. A population-based study of school scoliosis screening. JAMA. 1999;282(15);1427–32. 50 Debnath et al./ IP Journal of Paediatrics and Nursing Science 2025;8(2):45-50
- Nissinen M, Heliovaara M, Ylikoski M, Poussa M. Trunk asymmetry and screening for scoliosis: a longitudinal cohort study of pubertal school children. Acta Paediatr. 1993;82(1):77–82.
- Normand E, Franco A, Marcil V. Nutrition and physical activity level of adolescents with idiopathic scoliosis: a narrative review. Spine J. 2020;20(5):785–99.
- Binkley N, Ramamurthy R, Krueger D. Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinol Metab Clin North Am. 2010;39(2):287–301.
- Mayes T, Anadio JM, Sturm PF. Prevalence of vitamin D deficiency in pediatric patients with scoliosis preparing for spinal surgery. Spine Deform. 2017;5(6):369–73.
- Hampton M, Brewer P, Athanassacopoulos M, Breakwell LM, Cole AA, Michael ALR. Prevalence and significance of Vitamin D deficiency in patients undergoing corrective surgery for adolescent idiopathic scoliosis. Int J Spine Surg. 2022;16(1);202–7
- Bolek-Berquist J, Elliott ME, Gangnon RE, Gemar D, Engelke J, Lawrence SJ, et al. Use of a questionnaire to assess vitamin D status in young adults. Public Health Nutr. 2009;12(2):236–43.
- Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med. 2004;158(6):531–7.
- Zavatsky JM, Peters AJ, Nahvi FA, Bharucha NJ, Trobisch PD, Kean KE, et al. Disease severity and treatment in adolescent idiopathic scoliosis: the impact of race and economic status. Spine J. 2015;15(5):939–43.
- Wong AYL, Samartzis D, Cheung PWH, Cheung JPY. How common is back pain and what biopsychosocial factors are associated with back pain in patients with adolescent idiopathic scoliosis? Clin Orthop Relat Res. 2019;477(4):676–86.
- Lin T, Meng Y, Ji Z, Jiang H, Shao W, Gao R, et al. Extent of depression in juvenile and adolescent patients with idiopathic scoliosis during treatment with braces. World Neurosurg. 2019;126:e27–e32.
- Chang WP, Lin Y, Huang HL, Lu HF, Wang ST, Chi YC, et al. Scoliosis and the subsequent risk of depression: a nationwide population-based cohort study in Taiwan. Spine. 2016;41(3);253–8.
- Ravindra VM, Godzik J, Dailey AT, Schmidt MH, Bisson EF, Hood RS, et al. Vitamin D levels and 1-year fusion outcomes in elective spine surgery: a prospective observational study. Spine (Phila Pa). 2015;40(19):1536–41.
- Hawes M. Impact of spine surgery on signs and symptoms of spinal deformity. Pediatr Rehabil. 2006;9(4):318–39.
- Wenger DR, Mubarak SJ, Leach J. Managing complications of posterior spinal instrumentation and fusion. Clin Orthop Relat Res. 1992;284:24.
- Metzger M, Kanim L, Zhao L, Robinson ST, Delamarter RB. The relationship between Vitamin D status and successful spinal fusion. Spine J. 2015;13(9):S53.
- Kerezoudis P, Rinaldo L, Drazin D, Kallmes D, Krauss W, Hassoon A. et al. Association between Vitamin D deficiency and outcomes following spinal fusion surgery: a systematic review. World Neurosurg. 2016;;95:71–6.